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KMID : 0665220090220040639
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Korean Journal of Food and Nutrition
2009 Volume.22 No. 4 p.639 ~ p.643
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In Vitro Antineoplastic Effects of Chitosan Hydrolysates on Various Tumor Cell Lines
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Park Heon-Kuk
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Abstract
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In this study, the antineoplastic effects of chitosan hydrolysates were assessed. The chitosan hydrolysates showed no cytotoxicity in in vitro trials using the normal cell line, Vero E6(Africa green monkey kidney cells). The value of the chitosan hydrolysates on Vero E6 was 1,107.95 . The hydrolysates exhibited in vitro antineoplastic activity in five human tumor (lung carcinoma, bladder carcinoma, colon carcinoma, stomach carcinoma, breast carcinoma) cell lines. The values of the hydrolysates on A549, J82, SNU-C4, SNU-1, and ZR75-1 cells were 421.06, 417.99, 445.54, 380.65 and 460.49 , respectively.
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KEYWORD
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chitosan hydrolysates, cytotoxicity, antineoplastic effects
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